Composition
Paragesic-C tablet: Each tablet contains Paracetamol BP 500 mg and Caffeine Anhydrous BP 65 mg.
Pharmacology
Paragesic-C is a combination of Paracetamol and Caffeine which is one of the safest and most widely used analgesic and antipyretic. Paragesic-C produces analgesic action by elevation of pain threshold and antipyresis through action on the hypothalamic heat regulating center. Paragesic-C exerts significantly milder side effects and most unlikely to produce many of the side effects associated with Aspirin and NSAIDs.
Paracetamol is rapidly and completely absorbed from the GIT following oral administration. The drug is extensively metabolized in liver and it has plasma half life of 1.5 to 3.0 hours. Paracetamol is not bound to plasma proteins to any extent.
Indication
• Fever
• Headache, toothache, earache, bodyache, myalgia, dysmenorrhoea, neuralgia and sprains
• Rheumatic and Osteoarthritis pain
Dosage & administration
Adults & Elderly: 1-2 tablets three to four times daily. Do not exceed 8 tablets in 24 hours.
Children: Not recommended for children under 12 years.
Contra-indication
Known sensitivity to Paracetamol.
Warning & precaution
Paracetamol should be given with caution to patients with impaired kidney or liver function. Paracetamol should be given with care to patients taking other drugs that affect the liver.
Side effects
Side effects are significantly mild, though hematological reactions have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.
Use in pregnancy & lactation
Pregnancy: Paracetamol is safe in all stages of pregnancy and lactation.
Lactation: Paracetamol and caffeine are excreted in breast milk, so caution should be exercised when administered to a nursing woman.
Use in children & adolescents
Not recommended for children under 12 years.
Drug interaction
May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use. Accelerated absorption with metoclopramide and domperidone. May increase serum levels with probenecid. May increase serum levels of chloramphenicol. May reduce absorption with colestyramine within 1 hr of admin. May cause severe hypothermia with phenothiazine.
Overdose
Moderate overdose: 4-10 gm/day
Excessive overdose: More than 10 gm/day
Liver damage may become apparent 12-48 hours after ingestion. In severe poisoning hepatic failure may progress to encephalopathy, coma and death.
Storage
Keep out of the reach of children. Keep below 30°C, protect from light.
Packing
Paragesic-C tablet: Each Box contains 10x10's tablet in blister pack.
